Darshana V. Nadkarni, Ph.D.

Recruitment for Biotech & Medical Device companies Training & Consulting in Diversity and Inclusion

Homepage: https://darshanavnadkarni.wordpress.com

JOBS – November, 2020


Success, Business Woman, Career, Jump, Risk, Reach, Job

Please see my current opportunities below. All opportunities are for local (US based) candidates with valid work visa with all required industry experience.  If you have an interest then please send an email (resume as an attachment) at wd under score darshana at hot mail or find me on Linkedin.

Quality Engineer – North San Jose, CA

There is immediate opportunity for Quality Engineer in well funded startup by a veteran leader with a world class team. JD will be posted soon but meanwhile please send CV.

Quality Engineer – South San Jose, CA

Exciting bay area start-up on catheter development to focus on improved outcomes of arterial disease has an immediate opportunity for Quality Engineer.

Responsibilities
Support QA/QC/QS functions and activities in a medical device manufacturing environment; Establish purchased materials RI acceptance criteria & perform RI; In-process/final device inspection; Technical Writing for Design History File documents etc, Regulatory & Quality System documents; Design, write & perform equipment qualifications & process validations; establish & maintain equipment calibration & maintenance; support team, contract manufacturers & suppliers with robust & statistically valid testing, sample size selection, monitoring & analysis requirements

Requirements
5+ years medical device work experience (vascular catheter exp preferred), formal statistics training, Validation protocol design & report writing exp, exp to work in & maintain compliance of a certified QMS related to configuration control, document control & change control, enthusiasm for producing cool new products for catheter development. College education preferred.

Bioanalytical Lab Research Scientist – San Jose, CA

This is an exciting opportunity for a bioanalytical scientist to join world class team to work on drug-device projects, with the potential to dramatically change patient outcomes. Position, salary, and benefits are commensurate with experience, with possibility of option grants!!

Required: Background in medical device or pharma testing & regulatory development. Experience in preclinical and clinical research is a must. The candidate must have technical training in biochemistry and/or pharmaceutical sciences with experience using lyophilization, Karl Fischer titration, and HPLC. Experience with biochemical analysis such as spectrophotometric and fluorescence immunoassays, and LC-MS is a plus. Also required, degree in biochem or pharma sciences w. 2+ years experience, extensive exp in various analytical techniques & bioanalytical assays.

Responsibilities: Lead projects on biologic formulation, drug product process development; Executes experiments based on protocols and implement; Develop & maintain documentation,  test methods, study protocols, SOPs, worksheets, forms, and reports; Design and manage data from complex experiments including preliminary statistical analysis; literature searches; Maintain lab & assay operations notebook, equipment, supplies, computer files; Support regulatory efforts.

Bioanalytical Lab Scientist – San Jose, CA

There is an exciting opportunity for a bioanalytical scientist to join a team working on drug-device combinations projects w/ potential to change patient outcomes. Attractive benefits package with competitive salary is offered and option grants makes this exciting opportunity. Perform literature search, routine data management, tabulate & graph results, support regulatory efforts & manage lab supplies, safety, equipment. 

Responsibilities: Perform bioanalytical assays for the quantification of the analytes in in-vitro, preclinical and clinical samples; Participate in the development of in vitro/in vivo models by performing a variety of microplate assays independently with minimal supervision; Configure, program and troubleshoot laboratory automated platforms; Optimize existing automated processes to improve efficiency, throughput, robustness and quality. Perform literature search, routine data management, tabulate & graph results, support regulatory efforts & manage lab supplies, safety, equipment.

Required: Background in medical device or pharma & exp in preclinical and clinical research is a must. Also required, background in biochemical analysis such as spectrophotometric, fluorescence immuno assays, HPLC, CE, LC-MS. exp w/ microplate assays is must and experience with Luminex MapX technology is a plus. BS + 3 yrs work exp or MS + 1 yr exp and exp in writing reports & SOPs, knowledge of statistical software like Excel, GraphPad, Prism & Softmax Pro and hands-on exp in automation & liquid handling in a bioanalytical lab is required.

Senior scientist role requires 5+ years work experience.

Senior Scientist/ Dir/ VP
S. San Francisco, CA

Senior Scientist/ Director/ VP (commensurate with experience)

An early stage biotechnology startup with patented technology for engineering mammalian cells to vastly increase productivity for therapeutic proteins & disrupt biologics manufacturing, has two exciting openings. (The company has backing from J&J).

Job Functions: The work will involve vector design & preparation, transfection, cell culture, cloning & screening, flow cytometry & other related molecular and cellular biology techniques. Collaboration with co-workers &  pharmaceutical company customers is essential for this position.

Requirements: Candidate is required to have Ph.D. plus multiple years of experience with cell line creation, mammalian cell culture expertise, know regulatory landscape related to creating & testing cells for GMP manufacturing; exp. with molecular biology techniques for creating vectors & transfecting cells: exp with protein assays, with a goal to further develop the technology toward full commercialization. Experience with flow cytometry, cell banking, transposase transfection methods a huge plus.

Manufacturing Engineer

There is immediate opportunity for Manufacturing Engineer in San Jose, CA, in a well funded startup by a veteran leader with a world class team. JD will be posted soon but meanwhile please send CV.

Senior & Junior Mechanical Engineers – San Jose, CA

A bay area company with world class team, has an exciting opening for Senior & Junior Mechanical Engineers to design, develop & validate semi or fully automated equipment used for scale-up of high volume, disposable devices.

Responsibilities: Develop concepts & ideas for improving tooling, create new tooling, evaluate current manufacturing processes & workflows, take ownership of design, create User Requirements Specs, conduct concept reviews, show proof of concept through prototyping, support test data, coordinate with stakeholders for V&V, launch & documentation, created 3D models, engineering drawings & bills of materials, participate in design FMEA, plan to mitigate risks, and work with outside vendors, machine shops, contract manufacturers.
Requirements: BS in ME plus 3 to 13 years of medical device industry experience with complex mechanical/ electromechanical design, extensive experience with precision mechanisms pneumatics, servo systems, tooling/ fixtures, motors, belts/ pulleys, gears, actuators, sensors and experience creating engineering drawings, BOMs, products specs is required. Also required knowledge of material properties, heat treatment & surface finish, understanding of DFM & lean manufacturing, and track record with medical device manufacturing methods, RDA reqgulations, ISO, cGMP & QMS standards is required. MS in ME, experience with plastic injection molding, knowledge of DOE, SPC, JMP/ Minitab, experience with metal stamping, laser cutting, chemical etching, familiarity with sterilization process & aseptic environment and PLC programming would be a big plus.

Mechanical Engineer R&D – San Jose, CA

Senior Mechanical Engineer is responsible for evaluating and improving the current drug delivery system by testing and optimizing components or sub-assemblies as needed. He/she will work with quality & regulatory to develop complete documentation for the device.

Responsibilities: Evaluate current design & identify opportunities for improvement, show proof of concept through prototyping and supporting test data, document internal design control SOPs, lead V&V activities, create 3D models, engineering drawings & bill of materials, create work instructions & manufacturing SOP’s, work with quality, and outside vendors, machine shops, contract manufacturers and comply with company’s policies & guidelines regarding quality & regulatory.

Qualifications: BS in ME + 5 years hands’on experience in medical device design environment, experience with creating engineering drawings, BOMs, product specs, experience with implementing product into manufacturing, knowledge of FDA regulations & ISO, cGMP, QMS standards, understanding of DFM & lean manufacturing, experience with machine shop tools & SolidWorks. Master’s degree in ME or BME and/or experience with plastic injection molding, a huge plus.

Senior Catheter Design Engineer – S. San Jose, CA

There is an immediate opportunity for a Senior Catheter Design Engineer with 15 to 20 years experience in catheter design engineering in a stealth mode company that is less than 2 years away from getting its first two devices 510 K approved and launched. The company is led by a visionary leader and has highly experienced engineering and management team.  This a hug opportunity to participate at grounds level in what is a truly exciting and game changing technology that is poised to change the quality of care of cardiac patients, with a potential to save millions of healthcare dollars, on regular basis. Experience is IVUS engineering a huge plus.

Manufacturing/ Test/ Quality Engineer – S. San Jose, CA

A stealth mode cardiovascular company with experienced engineering team, led by a serial entrepreneur, has an immediate opening for  Manufaturing/ Test/ Quality Engineer. This requires 10 plus years experience in the filed of catheter engineering.

Catheter Design Mechanical Engineer – S. San Jose, CA

A stealth mode cardiovascular company, led by a serial entrepreneur with prior experience in building a company, has an immediate opening for  Catheter Design Mechanical Engineer. The position requires 5 to 10 years of experience in catheter engineering, a can do, problem solving attitude, excellent conflict resolution skills and an ability to handle uncertainty. 

Program/ Project Manager – S. San Jose, CA

A stealth mode cardiovascular company with world class engineering team, led by a veteran leader with prior experience in building a company, has an opening for  Program Manger with experience of working in catheter engineering industry and a demonstrated history of managing projects all the way from conceptualization, team building, cost estimation, implementation, regulatory 510 (K) approval, and production support to launch. Experience in catheter engineering and leading 510K approval program is absolutely essential.

Supply Chain Management/ Strategy Leader – S. San Jose, CA

A stealth mode startup with exciting technology with potential to alter the quality of care of cardiac patients is looking for Supply chain management/ strategy leader. This position requires extensive experience across the end to end supply chain spectrum in Class 3 medical device industry. It requires proven track record of significant contributions to cost reduction and productivity improvement and experience in cross-functional leadership.

Senior Technician/ Manufacturing Engineer – S. San Jose, CA

A stealth mode cardiovascular company, led by a serial entrepreneur with prior experience in building a company, has an opening for Senior Technician/ Manufacturing Engineer with 4 plus years experience in catheter engineering. 

NGS Research Scientist – Foster City, CA

Job Functions: To work on NGS assays for RNA seq, single cell and immune profiling projects & work collaboratively to develop new assays based on requests from the commercial team. Design & execute on NGS assays including 10X single cell & TCR/BCR repertoire profiling; Perform proof-of-concept experiments to enable development of new NGS applications for epigenetic and immunotherapy solutions; Collaborate w bioinformatics scientists to assist in data interpretation for single cell & TCR projects & generate presentations & reports for commercial projects; Generate data for application notes for marketing & BD needs.

Qualifications: Masters in Genetics, Immunology, Cancer Biology, Molecular Biology or related field; 2+ yrs NGS experience. Also, Hands-on experience in NGS techniques including sample extractions, RNA-seq, 10X, library prep & exp in low-input & single-cell NGS applications & exp in designing, executing, & troubleshooting for molecular & cell biology techniques a plus.

Logistics Lab Associate – Foster City, CA

This position will report to the Lab Manager & will handle procurement, distribution, storage, delivery & inspection of incoming & outgoing products to the lab. 

Responsibilities: Maintain inventory system, procure lab supplies from verified vendors, provide monthly reporting, execute POs, drive cost optimization, negotiate w/ vendors/ service providers, liaise w/ lab scientists on inventory, for example, ensure kits/reagents are not expired, manage iSensix alarms, store items appropriately & efficiently, & keep in stock at all times general use items (such as gloves, pipette tips, PCR plates, etc), track NGS inventory, meet reporting deadlines, generate & discuss reports w/ lab managers, handle shipment of  receipts & support facility initiatives. Requires ability to move/ stock supplies weighing up to 45 lbs.

Requirements: Ability to work independently, 2-5 years prior work experience as lab assistant at biotech/ diagnostic/ pharma/ lab, attention to detail in written instructions & documentation, basic computer skills in Word, Excel, willingness to work in two different time zones.

Senior Electro-Mechanical Engineering Technician – San Jose, CA

Requires 15+ years of experience.

Mechanical Testing & Fixture Design  Engineer – Milpitas, CA

There is an immediate opening for mechanical testing and fixture design engineer. Good understanding of how to design and set up tests is required. Responsibilities include design unique tests, develop fixtures, report failtures, help improve manufacturing processes, support V&V testing, interface with manufacturing to implement new design updates into pilot manufacturing line and analyze data. BS in ME, fluency in SolidWorks, and 3-5 years of medical device industry experience is required.

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Poem: 101 things to do as we wait #election2020 outcome


On nail-biting ride of #election2020🤞🤞when patience befitting year 2020 is required, I’m sharing a poem I wrote when I was waiting for a young man to call me ❤️❤️. It’s tweaked slightly. See below🙏🙏

101 things to do as we wait for #election2020 outcome

Read a book, go for a walk, or a swim
Hike, jog, do it for fun or just on a whim
Call an old foe for that divide to mend
Or share a good laugh with a friend
Listen to the music and drink ice tea,
Or lemonade or just relax and be
Mop the floor, and do the dishes
Like Cinderella, hum and make wishes
Think of all the bills to pay
Or just let them be for another day
Wear lingerie that is cute and lacy
Or baggy pajamas that caught your fancy
Maybe it is Friday and you have that fish to fry
Or on Wednesday, shout and sigh and sigh and have a good cry
This is only a partial list of things to do
Perhaps now you can wait patiently, can you?

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JOBS: October, 2020


Covid-19 crisis: 6 pragmatic money tips if you have lost your job recently  | Business News,The Indian Express

Please see my current opportunities below. All opportunities are for local (US based) candidates with valid work visa with all required industry experience.  If you have an interest then please send an email (resume as an attachment) at wd under score darshana at hot mail or find me on Linkedin.

Senior & Junior Mechanical Engineers

A bay area company with world class team, has an exciting opening for Senior & Junior Mechanical Engineers to design, develop & validate semi or fully automated equipment used for scale-up of high volume, disposable devices.

Responsibilities: Develop concepts & ideas for improving tooling, create new tooling, evaluate current manufacturing processes & workflows, take ownership of design, create User Requirements Specs, conduct concept reviews, show proof of concept through prototyping, support test data, coordinate with stakeholders for V&V, launch & documentation, created 3D models, engineering drawings & bills of materials, participate in design FMEA, plan to mitigate risks, and work with outside vendors, machine shops, contract manufacturers.
Requirements: BS in ME plus 3 to 13 years of medical device industry experience with complex mechanical/ electromechanical design, extensive experience with precision mechanisms pneumatics, servo systems, tooling/ fixtures, motors, belts/ pulleys, gears, actuators, sensors and experience creating engineering drawings, BOMs, products specs is required. Also required knowledge of material properties, heat treatment & surface finish, understanding of DFM & lean manufacturing, and track record with medical device manufacturing methods, RDA reqgulations, ISO, cGMP & QMS standards is required. MS in ME, experience with plastic injection molding, knowledge of DOE, SPC, JMP/ Minitab, experience with metal stamping, laser cutting, chemical etching, familiarity with sterilization process & aseptic environment and PLC programming would be a big plus.

Mechanical Engineer R&D – San Jose, CA

Senior Mechanical Engineer is responsible for evaluating and improving the current drug delivery system by testing and optimizing components or sub-assemblies as needed. He/she will work with quality & regulatory to develop complete documentation for the device.

Responsibilities: Evaluate current design & identify opportunities for improvement, show proof of concept through prototyping and supporting test data, document internal design control SOPs, lead V&V activities, create 3D models, engineering drawings & bill of materials, create work instructions & manufacturing SOP’s, work with quality, and outside vendors, machine shops, contract manufacturers and comply with company’s policies & guidelines regarding quality & regulatory.

Qualifications: BS in ME + 5 years hands’on experience in medical device design environment, experience with creating engineering drawings, BOMs, product specs, experience with implementing product into manufacturing, knowledge of FDA regulations & ISO, cGMP, QMS standards, understanding of DFM & lean manufacturing, experience with machine shop tools & SolidWorks. Master’s degree in ME or BME and/or experience with plastic injection molding, a huge plus.

Senior Catheter Design Engineer – S. San Jose, CA

There is an immediate opportunity for a Senior Catheter Design Engineer with 15 to 20 years experience in catheter design engineering in a stealth mode company that is less than 2 years away from getting its first two devices 510 K approved and launched. The company is led by a visionary leader and has highly experienced engineering and management team.  This a hug opportunity to participate at grounds level in what is a truly exciting and game changing technology that is poised to change the quality of care of cardiac patients, with a potential to save millions of healthcare dollars, on regular basis. Experience is IVUS engineering a huge plus.

Manufacturing/ Test/ Quality Engineer – S. San Jose, CA

A stealth mode cardiovascular company with experienced engineering team, led by a serial entrepreneur, has an immediate opening for  Manufaturing/ Test/ Quality Engineer. This requires 10 plus years experience in the filed of catheter engineering.

Catheter Design Mechanical Engineer – S. San Jose, CA

A stealth mode cardiovascular company, led by a serial entrepreneur with prior experience in building a company, has an immediate opening for  Catheter Design Mechanical Engineer. The position requires 5 to 10 years of experience in catheter engineering, a can do, problem solving attitude, excellent conflict resolution skills and an ability to handle uncertainty. 

Program/ Project Manager – S. San Jose, CA

A stealth mode cardiovascular company with world class engineering team, led by a veteran leader with prior experience in building a company, has an opening for  Program Manger with experience of working in catheter engineering industry and a demonstrated history of managing projects all the way from conceptualization, team building, cost estimation, implementation, regulatory 510 (K) approval, and production support to launch. Experience in catheter engineering and leading 510K approval program is absolutely essential.

Supply Chain Management/ Strategy Leader – S. San Jose, CA

A stealth mode startup with exciting technology with potential to alter the quality of care of cardiac patients is looking for Supply chain management/ strategy leader. This position requires extensive experience across the end to end supply chain spectrum in Class 3 medical device industry. It requires proven track record of significant contributions to cost reduction and productivity improvement and experience in cross-functional leadership.

Senior Technician/ Manufacturing Engineer – S. San Jose, CA

A stealth mode cardiovascular company, led by a serial entrepreneur with prior experience in building a company, has an opening for Senior Technician/ Manufacturing Engineer with 4 plus years experience in catheter engineering. 

NGS Research Scientist – Foster City, CA

Job Functions: To work on NGS assays for RNA seq, single cell and immune profiling projects & work collaboratively to develop new assays based on requests from the commercial team. Design & execute on NGS assays including 10X single cell & TCR/BCR repertoire profiling; Perform proof-of-concept experiments to enable development of new NGS applications for epigenetic and immunotherapy solutions; Collaborate w bioinformatics scientists to assist in data interpretation for single cell & TCR projects & generate presentations & reports for commercial projects; Generate data for application notes for marketing & BD needs.

Qualifications: Masters in Genetics, Immunology, Cancer Biology, Molecular Biology or related field; 2+ yrs NGS experience. Also, Hands-on experience in NGS techniques including sample extractions, RNA-seq, 10X, library prep & exp in low-input & single-cell NGS applications & exp in designing, executing, & troubleshooting for molecular & cell biology techniques a plus.

Logistics Lab Associate – Foster City, CA

This position will report to the Lab Manager & will handle procurement, distribution, storage, delivery & inspection of incoming & outgoing products to the lab. 

Responsibilities: Maintain inventory system, procure lab supplies from verified vendors, provide monthly reporting, execute POs, drive cost optimization, negotiate w/ vendors/ service providers, liaise w/ lab scientists on inventory, for example, ensure kits/reagents are not expired, manage iSensix alarms, store items appropriately & efficiently, & keep in stock at all times general use items (such as gloves, pipette tips, PCR plates, etc), track NGS inventory, meet reporting deadlines, generate & discuss reports w/ lab managers, handle shipment of  receipts & support facility initiatives. Requires ability to move/ stock supplies weighing up to 45 lbs.

Requirements: Ability to work independently, 2-5 years prior work experience as lab assistant at biotech/ diagnostic/ pharma/ lab, attention to detail in written instructions & documentation, basic computer skills in Word, Excel, willingness to work in two different time zones.

Senior Electro-Mechanical Engineering Technician – San Jose, CA

Requires 15+ years of experience.

Mechanical Testing & Fixture Design  Engineer – Milpitas, CA

There is an immediate opening for mechanical testing and fixture design engineer. Good understanding of how to design and set up tests is required. Responsibilities include design unique tests, develop fixtures, report failtures, help improve manufacturing processes, support V&V testing, interface with manufacturing to implement new design updates into pilot manufacturing line and analyze data. BS in ME, fluency in SolidWorks, and 3-5 years of medical device industry experience is required.

Patent Attorney

This position will be responsible for preparing patent applications and will prosecute company’s global patent portfolio. 3+ years of medical device industry experience as a scientist or engineer plus 3+ years of experience as a patent prosecutor is required. Also required USPTO registration and CA license. Highly preferred, 3+ years experience designing/ developing medical devices and at least 3-% of patent prosecution experience across a variety of medical devices and a basic understanding of pharmacodynamics and pharmacokinets and a degree in EE or material science.

Leadership Opportunity – Milpitas, CA

There is a senior level leadership opportunity that requires prior experience with leading a neurological medical device company.

Leadership Opportunity – Union City, CA

A senior level leadership opportunity requires experience with taking a biotech company public.

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For here or to go? Movie Review


Not only do we humans get used to an easier life with some comforts, but when we begin to get settled in a place where we begin to build our career in our youth and make friends and build aspirations then we’re simultaneously not planning an alternate lifestyle. However, students who come to study in the US are stuck in a limbo of uncertainty for years, and among them are over a million young people from India. Pulled between a sense of cultural displacement, strong familial ties back home and climbing the career ladder of success in the US, their dreams are just beginning to come into a sharper focus as they enter the world of work, after completion of their studies. 

The Impermanence of Being an H-1B Immigrant

When the recession hit in 2008, young Vivek Pandit (Ali Fazal) with brilliant ideas for a tech startup, encountered problems with his visa renewal. Faced with the prospect of going home, his friends advise him that If the job is over then they have to be ready to leave. Life in a different society will call for different priorities and accordingly they say, “Go to the Golden gate, and take a few pics that you can also use for shadi.com (Indian matrimonial site)”.

Vivek’s accidental meeting with Shweta  (Melanie Kannokada), a second generation Indian or ABCD as they are called by desi circles, results in a sprouting romance. However, Vivek’s uncertain future suddenly ends a relationship that looked promising. Vivke laments, “Temporary is not how you feel living here, it’s also how others see you”. Meanwhile, Shweta’s author father Vishwanath Prabhu (Rajit Kapur) is on a speaker’s circuit advising young Indians to return home and make a difference in India.

Vivek’s townhouse roommates include Sam (Samrat Chakrabarti), a gay co-worker Lakshmi (Omi Vaidya), and Amit (Amitosh Nagpal). Their innocent mistake or allowing a friend who is an illegal immigrant, lands them on the FBI’s watch list. Each of them is also navigating a set of cultural and practical challenges. Omi is reluctant to visit his family back home, from the fear that he may be pressured to get married and they will not accept his being gay. Amit has to present his passport to the FBI but has misplaced it.

As the movie progresses it begins to become clearer that among the blessings these young people have are their families who care deeply for their happiness and love and support of friends who are stuck in similar moral dilemmas and navigating practical challenges. Amit bring many lighter moments. Living in a shadow of uncertainty he says, Zindagi sirf guarantee pe nahi, umido pe bhi chalti hai (life doesn’t just run on certainly, it also unravels on the basis of hope).

Writer-producer Rishi S. Bhilawadikar’s script is fast moving and hits a range of diverse points that highlight the complexities of living a life of uncertainty. Director Rucha Humnabadkar has avoided over-dramatizing any of these challenges, while maintaining focus. 

In the end, what you are impressed with is the quiet tenacity and adaptability of these bright young people. Vivek says, Akhir zindagi sirf umiddo pe nahi, apni nazariya pe bhi to chalti hai (after all, life doesn’t just unfold on the basis of hope, but also unravels as per your perspective and efforts).

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Daughters of Destiny – Serial Review


At a school for poor children in India, price of attendance is paying it  forward | PBS NewsHour

Daughters of Destiny is a serial documentary that features a story of one school trying to make a meaningful difference, change the world, and bring hope where none exists, where destiny is pre-carved; in a country, with a population of over a billion people.

Doctor Abraham George completed his education in the United States and found and sold a company. Having made his fortune, he set about trying to change the world. He started a school, Shanti Bhavan, with a mission to improve the lives of the families in the lowest caste in India, the untouchables. While India has made significant strides in creating wealth, most of the wealth has been created in the top 10%, while there are 300M people considered to be Dalits or untouchables, often trapped in a cloying cycle of poverty. The school started with a bunch of kids that included boys and girls in equal numbers. The idea was to remove them from their homes and immerse them into a unique cultural and educational system, to shape them into becoming future leaders, each of them expected to commit to bringing along at least 100 others out of a cycle of injustice and poverty.  Only one child per family was selected.

While telling the story of the school, the documentary focuses on a few girls and their struggles, opportunities and challenges. Thenmozhi, seven, is a sweet, talkative girl aspiring for a job called science but finds that education holds her interest on and off.  As the documentary proceeds, Manjula, a 14 year old will be expected to help her family come out of the spiralling debt. Preetha could be any ordinary teenager anywhere in the world. She loves music and aspires to have a career in music and is repeatedly advised to choose traditional subjects for her college degree so she can become financially independent. Shilpa nurtures the dream to become a journalist and carries a big weight on her shoulders to give voice to those who may not be able to speak for themselves. And Karthika wants to become a human rights lawyer and help and empower poor people to seek justice and equality, under the law.

It's GRADUATION time at Shanti Bhavan! » Blog Archive » Shanti Bhavan  Children's Project

This is not an easy road to accomplishing their dreams. Each of these girls encounter various challenges. After getting used to living in clean surroundings of the school where their only job is to study and keep their dorms clean, twice every year, they go back home, where their struggling parents are living in huts, doing back breaking laborer’s jobs, sleeping together on the floor, have meagre rations, and their siblings who have demons of their own, who haven’t been the ones selected to go to Shanti Bhavan, who are still trapped in the same familiar pattern of child labor, lack of education options, likely early marriages, and same cycles of poverty, living out their destiny with whatever is predetermined and written on their foreheads by destiny.  These girls are prepared at the school to be patient, humble and understanding when they are back home.

While childhood is easy, more challenges begin when these children graduate from the schools and enter into colleges of their choice (continuing education is paid by Dr. George at Shanti Bhavan). Now they live in a broader world of haves and have-nots, mingle in a world that harbors preconceived notions about cast and wealth and status and station in life. Moreover, as their responsibilities towards their families come closer and into sharper focus, the differences between who they have become and the families they have left behind, become clearer. Questions emerge. “What if it was not me but my sibling who was selected? By 14 then I would be married and maybe even have a kid”. “I got a lottery but do I really belong in this world? Do I belong in any world? Can I ever live at my home again”?  “Was it worth it to be transplanted like this from one world to another and what was the meaning of it”? Some children hold deep guilt about how their siblings’ lives turned out, as compared to theirs. Some ask, “can one really transcend history, their past and destiny”?

As children navigate the challenges, negotiate their careers, and dream ahead, one can see that in hustling bustling teeming India, a small history is being made through the accomplishments of these children. In wealthier nations like America, there are albeit other paths besides education, to live a more fulfilled life, to live with equality, freedom and pride. But in India, there is one sure path to live a life of dignity and freedom and it is through meaningful education. But these future leaders at Shanti Bhavan also receive emotional support, cultural education, civic lessons and are let loose into the world with a boat load of expectations to carry forward their debt to society. A girls says towards the end that as per Indian philosophy, if one gets one’s lot in the world according to their karma of past life and therefore if karma is something that already occurred in the past then “I must be able to shape my future”. Though it is challenging for these children to blend their two realities of the world they came from and the world they are actively creating, we can see that for many, everything comes together as they mature and develop wisdom to accept both and yet are not fully shaped by either.

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નિયતિ ની દીકરીઓ (Daughters of Destiny) – સીરીયલ સમીક્ષા


સફળતા શું છે?

Shanti Bhavan (@ShantiBhavan) | Twitter

કાળી મજૂરી કરતી અને માથા ઉપર પાણા ઉપાડતી વિધવા મા ની દીકરી જયારે ભણીગણી ને વકીલ બને ત્યારે આપણે તેને સફળતા માનીએ ખરું ને? પણ ત્યારે કોઈ તેને કહે કે અમે તેને સફળતા નહિ ગણીએ તો આપણને વિસ્મયતા થાય। સત્ય ઘટના ઉપર આધારિત ડોટર્સ ઓફ ડેસ્ટીની ઉર્ફ નિયતિ ની દીકરીઓ નામની સીરીઅલ માં આ વાત નું વર્ણન છે.

ડૉક્ટર જોર્જ ભારત થી અમેરિકા શિક્ષણ માટે આવ્યા અને ત્યાર બાદ એક કંપની શરુ કરી. ખુબ સફળ એ કંપની વેંચીને પૈસા બનાવ્યા બાદ તેઓ પૈસા લઈને ભારત પાછા ફર્યા અને શાંતિ ભવન શાળાની સ્થાપના કરી. બાળકો ભણવા આવે અને પાછા પોતાના ઘરે જતા રહે તે તેમની સ્થિતિ માં શક્ય જ નહોતું. ઘણા બાળકો ઝૂંપડામાં રહેતા હતા, ભણવા માટે એકાંત, વીજળી વગેરેની વ્યવસ્થા નહોતી, ઘણા બાળકો ઉપર સાત, આઠ વર્ષે માતાપિતા ના કામ માં મદદ કરવાનું દબાણ રહેતું. અને તે ઉપરાંત આ બાળકોને કોઉન્સેલિંગ, મેન્ટરીંગ અને એક્સટ્રા કૅરીક્યુલર એકટીવિટીસ ની પણ જરૂર હતી. આજુબાજુના સૌથી ગરીબ દલિત બાળકોને સર્વોત્તમ ભણતર, સાંસ્કૃતિક શિક્ષણ સાથે તેમના રહેવાની વ્યવસ્થા કરી. પછી ઝૂંપડીમાં જઈને ગરીબ માં બાપ પાસે તેમના બાળકો ને શાંતિ ભવનને સોંપી દેવાની વિનંતી કરી. એવા માતાપિતા જે કોઈ પણ સમયે પોતાના બાળકોનું ભલું ઇચ્છતા હોય છે તેમણે પોતાના દિલ ઉપર પથ્થર રાખીને તેમના નાના નાના ભુલકાઓને શાંતિ ભવન શાળા માં ઉછેરવા માટે સોંપી દીધા. બાળકો વર્ષમાં બે વખત પોતાના ઘરે વેકેશન ગાળવા જતા અને તે સિવાયનું બધુજ શિક્ષણ અંગ્રેજીમાં લઇ અને પછી શાંતિ ભવન ના ખર્ચે કોલેજ માં ભણવા ગયા. અને ત્યાર બાદ તેમને સારી સારી નોકરી ઓ મળી. ત્યારે ડોક્ટર જોર્જે બાળકોને કહ્યું કે તમે આ તમારી સિદ્ધિને સફળતા નહિ માનતા.

તમે જે ભણતર અને નાગરિકી શિક્ષણ પ્રાપ્ત કર્યું છે તેના દ્વારા માત્ર તમારી જિંદગી માં તમે વ્યવસાયિક અને ભૌતિક રીતે સ્થાયી થાઓ, જિંદગીમાં ક્યારેય ન પ્રાપ્ત કર્યું હોય તેને મેળવી શકો તે તમારા નસીબ અને અમારી ખુશી. ભારત માં તો કહેવાય છે કે વિધાતા લેખ લખે તેને કોઈ ટાળી નથી શકતું. અને છતાં પણ તમને મદદ મળી ત્યારે તેમાં તમારી અખંડ પરિશ્રમ નું મિશ્રણ કરીને વિધિએ લખેલ લેખ ને તમે બદલી શક્યા। તમારી ખુશી અને આ આનંદ ના પ્રસંગે અમે તમારી જોડે જોડાઈએ છીએ અને આનંદ અનુભવીએ છીએ. પણ અહીં અટકતા નહિ. આ સફળતા નથી. અમે તમારી ખરી સફળતા ત્યારે ગણીશું જયારે તમે ઓછા માં ઓછા બીજા સો બાળકોને જિંદગીમાં આગળ લાવો અને તેમના નસીબ ને બદલવામાં મદદ કરો.

પેલી વકીલ છોકરીએ શું કર્યું? તેણે વકીલાત શરુ કરતા જ સૌથી પહેલો કેસ લીધો તેની વિધવા માં માટેનો અને તેની સાથે 30 વર્ષ થી પથ્થર ની ખાણ માં પથ્થર કાપતા અને ત્યાંજ રહેતા બધા મજૂરોનો। દરેક કુટુંબને તેના હકની જમીન, મકાન, દાક્તરી સગવડ અને બાળકો માટે શાળાની સગવડ માટે ની કોર્ટ માં અરજી કરતો તે કેશ આગળ વધી રહ્યો છે. જિંદગીમાં સફળતાનો કોઈ માપદંડ નથી અને કોઈની સફળતાને આધારે કે તેની સરખામણી કરતા આપણી સફળતા નક્કી નથી થતી. બલ્કે જિંદગીમાં આપણી સફળતા શું છે તે તેની અસર ને આધારે અને આપણા સિદ્ધાંત પ્રમાણે આપણે જ નક્કી કરવાનું છે. આ સીરીઅલ નેટફ્લિક્સ માં જોવા મળી શકશે.

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Retablo – Movie Review


Directed by Alvaro Delgado Aparicio, Retablo is a film jointly produced with participation of Peru, Germany and Norway. Retablo won Best Peruvian Film Award at Festival deCine de Lima & at Berlin International Film Festival, in 2018, it won Teddy Award as the best LGBTQ-themed debut film. 

Movie Review: Retablo - Gaylaxy Magazine

It centers around a 14 year old Perfuvian boy, Segundo Paucar (Junior Bejar) who is being trained by his father, Noe (Amiel Cayo), to become an artisan and continue with the family legacy of making beautiful retablos. These brightly painted wooden cabinets were sometimes commissioned by large families and they featured the family members and sometimes they were commissioned by churches. Father and son duo also made small generic retablos to sell in the tourist markets. Sedundo shares a very special bond with his father and father is immensely proud of the skills and enthusiasm that his young son displayed. 

However, Segundo’s beautiful little world fell apart when he saw his father engage in a homosexual act. Guilt and shame began to eat him inside. But that was only the start of their problems. Some time later, Noe was caught in the act, by the villagers. This was a small close knit, traditional community of people who took simple pleasures in community celebrations. The same community where people depended on each other in their hour of need, was also totally intolerant of a different way of life. Noe was not only insulted and spurned by the villagers but also was badly beaten. His wife Anatolia, (Magaly Solier) left him. 

The flow of the film is so natural that it is hard to imagine at which point it becomes intense. Junio Bejar displays a range of emotions from pride about his family to disgust and shame to disillusionment to deep inner strength when he decides to not accompany his grieving mother who leaves her husband, but instead stays with his father who is beaten and left as an outcast.

The film shows the challenges that LGBTQ people often have to navigate in diverse societies. And it shows that  the cost of exclusion is borne not only by the individual but his family as well. On a scale of 1 to 5 with 5 being excellent, I rate it a 4.2. Retablo is available on Netflix.

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JOBS – September, 2020


Office, Notes, Notepad, Entrepreneur

Please see my current opportunities below. All opportunities are for local (US based) candidates with valid work visa with all required industry experience.  If you have an interest then please send an email (resume as an attachment) at wd under score darshana at hot mail or find me on Linkedin.

Senior Mechanical Engineer

A bay area company with world class team, has an exciting opening for Senior Mechanical Engineer with experience in developing class 3 medial device products and understanding core research that went in to developing that product.  Requires an ability to run experiments and generate viable ideas.  This is an opportunity to participate at grounds level in an opportunity with high potential outcome.

Senior Catheter Design Engineer – S. San Jose, CA

There is an immediate opportunity for a Senior Catheter Design Engineer with 15 to 20 years experience in catheter design engineering in a stealth mode company that is less than 2 years away from getting its first two devices 510 K approved and launched. The company is led by a visionary leader and has highly experienced engineering and management team.  This a hug opportunity to participate at grounds level in what is a truly exciting and game changing technology that is poised to change the quality of care of cardiac patients, with a potential to save millions of healthcare dollars, on regular basis. Experience is IVUS engineering a huge plus.

Manufacturing/ Test/ Quality Engineer – S. San Jose, CA

A stealth mode cardiovascular company with experienced engineering team, led by a serial entrepreneur, has an immediate opening for  Manufaturing/ Test/ Quality Engineer. This requires 10 plus years experience in the filed of catheter engineering.

Catheter Design Mechanical Engineer – S. San Jose, CA

A stealth mode cardiovascular company, led by a serial entrepreneur with prior experience in building a company, has an immediate opening for  Catheter Design Mechanical Engineer. The position requires 5 to 10 years of experience in catheter engineering, a can do, problem solving attitude, excellent conflict resolution skills and an ability to handle uncertainty. 

Program/ Project Manager – S. San Jose, CA

A stealth mode cardiovascular company with world class engineering team, led by a veteran leader with prior experience in building a company, has an opening for  Program Manger with experience of working in catheter engineering industry and a demonstrated history of managing projects all the way from conceptualization, team building, cost estimation, implementation, regulatory 510 (K) approval, and production support to launch. Experience in catheter engineering and leading 510K approval program is absolutely essential.

Supply Chain Management/ Strategy Leader – S. San Jose, CA

A stealth mode startup with exciting technology with potential to alter the quality of care of cardiac patients is looking for Supply chain management/ strategy leader. This position requires extensive experience across the end to end supply chain spectrum in Class 3 medical device industry. It requires proven track record of significant contributions to cost reduction and productivity improvement and experience in cross-functional leadership.

Senior Technician/ Manufacturing Engineer – S. San Jose, CA

A stealth mode cardiovascular company, led by a serial entrepreneur with prior experience in building a company, has an opening for Senior Technician/ Manufacturing Engineer with 4 plus years experience in catheter engineering. 

NGS Research Scientist – Foster City, CA

Job Functions: To work on NGS assays for RNA seq, single cell and immune profiling projects & work collaboratively to develop new assays based on requests from the commercial team. Design & execute on NGS assays including 10X single cell & TCR/BCR repertoire profiling; Perform proof-of-concept experiments to enable development of new NGS applications for epigenetic and immunotherapy solutions; Collaborate w bioinformatics scientists to assist in data interpretation for single cell & TCR projects & generate presentations & reports for commercial projects; Generate data for application notes for marketing & BD needs.

Qualifications: Masters in Genetics, Immunology, Cancer Biology, Molecular Biology or related field; 2+ yrs NGS experience. Also, Hands-on experience in NGS techniques including sample extractions, RNA-seq, 10X, library prep & exp in low-input & single-cell NGS applications & exp in designing, executing, & troubleshooting for molecular & cell biology techniques a plus.

Logistics Lab Associate – Foster City, CA

This position will report to the Lab Manager & will handle procurement, distribution, storage, delivery & inspection of incoming & outgoing products to the lab. 

Responsibilities: Maintain inventory system, procure lab supplies from verified vendors, provide monthly reporting, execute POs, drive cost optimization, negotiate w/ vendors/ service providers, liaise w/ lab scientists on inventory, for example, ensure kits/reagents are not expired, manage iSensix alarms, store items appropriately & efficiently, & keep in stock at all times general use items (such as gloves, pipette tips, PCR plates, etc), track NGS inventory, meet reporting deadlines, generate & discuss reports w/ lab managers, handle shipment of  receipts & support facility initiatives. Requires ability to move/ stock supplies weighing up to 45 lbs.

Requirements: Ability to work independently, 2-5 years prior work experience as lab assistant at biotech/ diagnostic/ pharma/ lab, attention to detail in written instructions & documentation, basic computer skills in Word, Excel, willingness to work in two different time zones.

Senior Mechanical Engineering Technician – San Jose, CA

Requires 15+ years of experience.

Senior Electro-Mechanical Engineering Technician – San Jose, CA

Requires 15+ years of experience.


Senior & Junior Mechanical Engineer – San Jose, CA

The Senior Mechanical Engineer is responsible for evaluating and improving the company’s current drug delivery system while maintaining high quality and reliability standards. This will be achieved by testing the system and optimizing components or subassemblies as needed. In addition, he/she will be required to work with quality and regulatory to develop complete documentation for the device. The successful candidate will work independently and use sound judgment to deliver optimal solutions. This is a hands-on position that requires interaction and collaboration with a cross-functional team.

Responsibilities

  • Evaluate the current design and identify opportunities to realize improvement in product consistency and increased throughput in a manufacturing environment
  • Show proof of concept through prototyping and supporting test data, and coordinate implementation with appropriate stakeholders
  • Take full ownership of documentation by following internal design control SOPs, leading verification/validation activities, and participating in phase reviews
  • Create 3D models, engineering drawings and bill of materials
  • Create comprehensive work instructions and manufacturing SOP’s
  • Work with quality to resolve any issues with components or processes
  • Establish working relationship with outside vendors, machine shops, contract manufacturers and manage the work accordingly
  • Comply with company’s policies and guidelines regarding quality and regulatory

Qualifications

  • Bachelor’s Degree in Mechanical Engineering
  • Senior engineer requires 10-12 years experience and junior engineer requires 3-5 years hands-on experience in a design environment
  • Experience with creating engineering drawings, BOMs, and product specifications
  • In-depth experience with complex mechanical systems that interact with biology
  • Prior experience in a medical device company
  • Experience with design control process for medical devices and implementation of product in to manufacturing
  • Working knowledge of FDA regulations and ISO, cGMP, QMS standards
  • Good understanding of DFM and lean manufacturing
  • Excellent verbal, written, presentation and interpersonal skills
  • Strong analytical and problem-solving skills
  • Knowledge and/or hands-on experience with machine shop tools
  • Proficiency with SolidWorks required
  • Creative, self-motivated, flexible to work in a small company environment and assume a wide variety of tasks

Preferred Qualifications

  • Knowledge /experience with plastic injection molding
  • Masters’ degree or higher in Mechanical Engineering or Biomedical Engineering

Mechanical Testing & Fixture Design  Engineer – Milpitas, CA

There is an immediate opening for mechanical testing and fixture design engineer. Good understanding of how to design and set up tests is required. Responsibilities include designing unique tests, developing fixtures, and analyzing the data. Additional duties may include reporting failures, and assisting in improving manufacturing processes to prevent prototype failures, support R&D with component design work, test fixture design, support verification testing, and interface with manufacturing to implement new design updates into the pilot manufacturing line.

Responsibilities

  • Work with multi-disciplinary teams to define tests and perform verification testing
  • Design and build appropriate test fixtures for completing the tests
  • Assist engineering and bio team on evaluation of device failures and complete test reports to review improvements with the team
  • Collaborate with manufacturing to create product assembly tooling, fixtures and work instructions
  • Assist R&D and manufacturing in process development, including molding, bonding processes for parts, and component design
  • Comply with company’s policies and guidelines regarding quality and regulatory

Qualifications

  • BS in Mechanical Engineering
  • 3-5 years of industry experience
  • Must be hands on and adept at building and debugging fixtures
  • Fluent with SolidWorks
  • Excellent verbal, written, presentation and interpersonal skills
  • Strong analytical and problem-solving skills
  • Creative, self-motivated, flexible to work in a small company environment and assume a wide variety of tasks

Preferred Qualifications
Prior experience in a medical device company desired

Leadership Opportunity – Milpitas, CA

There is a senior level leadership opportunity that requires prior experience with leading a neurological medical device company.

Leadership Opportunity – Union City, CA

A senior level leadership opportunity requires experience with taking a biotech company public.

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Covid updates – July, 2020


Virus, Covid, Science, Covid19

Here are some covid updates from last couple of weeks. I have gathered info from zoom sessions. For more details, accurate sources, and veracity, please research further.

  • CA expecting 19000+ deaths by Nov. 1
  • US covid deaths top 150,000
  • More than 6,300 covid cases in the US, are linked to colleges
  • After some decline in people dying, now daily death counts are rising in 21 states
  • 47% (that is, almost half the population) of US adults have some underlying condition that slightly increases the chance of severe covid illness
  • Blood glucose level of 7 or higher leads to 33% chance of dying 60% chance of contraction
  • Spain had 2,255 more cases in last 24 or so hours.  Britain imposed quarantine on travelers from Spain
  • WHO warns of new EBOLA outbreak in Congo
  • China reports biggest virus spike since end of Wuhan outbreak
  • India has the fastest growing coronavirus cases in the world
  • 23% of Delhi residents seem to have antibodies 
  • North Korea is reporting their first covid case
  • Plastic visors in place of masks are NOT effective
  • Israel & Japan experience huge spikes in covid cases
  • Chinese study found that people with type 2 diabetes had shorter telomere length
  • Study found that aerosoles in covid patients’ rooms, had live virus floating around even after 5-6 days
  • Research found no transmission of covid from infected moms to newborn babies, even after 2 weeks of breast feeding with proper cleaning protocols
  • In another study, pregnant women who had virus, their placenta also had virus
  • Study says mosquitoes cannot pass on covid from infected patients to non infected patients
  • From 3334 patients with covid in NY hospitalized, 16% had DVT, stroke or heart attacks
  • Presence of virus in the gut likely means that virus takes longer to leave the system and would lead to higher risk of liver injury
  • Spain study found that about 5% of those who contracted covid  in large cities had antibodies while only 3% of those of contracted covid near the coast, had antibodies
  • In one study, over 50% of people who contracted covid show some heart damage
  • 85 babies under age 1 tested positive in one county in Texas
  • Overwhelming fatigue, palpitations, muscle aches are symptoms that linger for 4-6 weeks after recovery from covid

On potential vaccines & treatments & safety products

  • There are 42 potential vaccines — Most in phase 1, 14 of them are in phase 2 and 4 are in phase 3 
  • Oxford/ AZ vaccine results look good in phase 1 / 2
  • China’s Sinopharm is in phase 3 trial for covid vaccine
  • Cage Bio developed sanitizers that offers protection for up to 4 hours
  • Steroid treatment slightly reduces the need for mechanical ventilation 
  • A client has very exciting and fascinating prevention strategy. If interested in investing then let me know & I’ll put you both in contact.
  • Boehringer Ingelheim identified 28 new antibodies to fight the virus

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સાથ વિષે….. (on togetherness in #Gujarati)


 

સાથ વિષે………

Michelangelo, Abstract, Boy, Child, Adult

કોઈકનો સાથ જીવન માં થોડી ક્ષણોનો હોય છે પણ આખું જીવન મહેકતું કરીને જાય. કોઈકનો સાથ આખી જિંદગી હોય પણ ન હોવા બરોબર અને વ્યક્તિ ક્યારેક રસમો રિવાજ ને સમાજ ને લીધે આખી જિંદગી કોઈકનો નગુણો સાથ નિભાવી લ્યે છે. કોઈકનો સાથ એક આદત બની જાય છે. અને મીરા સાથે કૃષ્ણનો સાથ હતો તેમ ક્યારેક સાથ શ્રદ્ધા ની અનુભૂતિ છે.  મીરાં ને કૃષ્ણ નો સાથ શ્રદ્ધા માં હતો તેથીજ મીરા ના શબ્દો માં સંવેદના થી તરબોળ એવા સાથ ના ઘણા રૂપ મળે છે. 

ક્યારેક મીરા શ્રી કૃષ્ણ ના સાથ ને ઝંખે છે
मीरा कहै प्रभु कब रे मिलोगे
तुम बिन नैण दुखारा॥
म्हारे घर आ प्रीतम प्यारा॥ 

ક્યારેક તે સાથ ની અમૂલ્યતા ને અનુભવે છે
जनम जनम की पूंजी पाई
जग में सभी खोवायो
पायो जी मैंने राम रतन धन पायो

ને ક્યારેક તે વિરહ ની વેદના માં જુરે છે.
प्रभु जी तुम दर्शन बिन
मोय घड़ी चैन नहीं आवड़े॥
अन्न नहीं भावे, नींद न आवे
विरह सतावे मोय।
घायल ज्यूं घूमूं खड़ी रे
म्हारो दर्द न जाने कोय॥

ને ક્યારેક તેમના સંગાથ માં જ જીવન જતું હોય તેમ સહજતાથી કહે છે
साजि सिंगार बांधि पग घुंघरू,
लोक-लाज तजि नाची॥
मैं तो सांवरे के रंग राची।

સાથ માં આ બધા રૂપ સમાય જાય છે.

Friends, Cat And Dog, Cats And Dogs, Pet, Domestic

મારા શબ્દોમાં…… 

સાથ લાગણી છે, સંવેદના છે, પ્રેમ છે
સાથે હોય તે જ પૂછે ને તું હેમખેમ છે?

સાથ માં સંગાથ હોવો જરૂરી નથી
ક્યારેક સાથ માત્ર આદત જેમ છે

સાથ માં મતભેદ છે સાથે ફરિયાદ છે
વિરહ ને વેદના ને ફરી થતું મિલન છે

સાથ માં વર્તાય વ્યક્તિનું વ્યક્તિત્વ
તેને બીજા પ્રત્યે કેવો રહેમ છે

સાથ માં હિસાબ કિતાબ પણ હોય
સમર્પણ, તો ક્યારેક સાથ લેણદેણ છે

જન્મતાંજ શ્વાસ સાથે સંકળાયેલ સાથ છે
તો જ મિલન વગર પણ આજે સૌ હેમખેમ છે 

 

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