Darshana V. Nadkarni, Ph.D.

Recruitment for Biotech & Medical Device companies Training & Consulting in Diversity and Inclusion

Homepage: https://darshanavnadkarni.wordpress.com

JOBS – May, 2020


Office, Notes, Notepad, Entrepreneur

Please see my current opportunities below. All opportunities are for local (US based) candidates with valid work visa and require deep industry experience.  If you have an interest then please send an email (resume as an attachment) at wd under score darshana at hot mail or find me on Linkedin.

Senior Mechanical Engineer – San Jose, CA


The Senior Mechanical Engineer is responsible for evaluating and improving the company’s current drug delivery system while maintaining high quality and reliability standards. This will be achieved by testing the system and optimizing components or subassemblies as needed. In addition, he/she will be required to work with quality and regulatory to develop complete documentation for the device. The successful candidate will work independently and use sound judgment to deliver optimal solutions. This is a hands-on position that requires interaction and collaboration with a cross-functional team. 

Responsibilities

  • Evaluate the current design and identify opportunities to realize improvement in product consistency and increased throughput in a manufacturing environment
  • Show proof of concept through prototyping and supporting test data, and coordinate implementation with appropriate stakeholders
  • Take full ownership of documentation by following internal design control SOPs, leading verification/validation activities, and participating in phase reviews
  • Create 3D models, engineering drawings and bill of materials
  • Create comprehensive work instructions and manufacturing SOP’s
  • Work with quality to resolve any issues with components or processes
  • Establish working relationship with outside vendors, machine shops, contract manufacturers and manage the work accordingly
  • Comply with company’s policies and guidelines regarding quality and regulatory

Qualifications

  • Bachelor’s Degree in Mechanical Engineering
  • 5 plus years hands-on experience in a design environment
  • Experience with creating engineering drawings, BOMs, and product specifications
  • In-depth experience with complex mechanical systems that interact with biology
  • Prior experience in a medical device company
  • Experience with design control process for medical devices and implementation of product in to manufacturing
  • Working knowledge of FDA regulations and ISO, cGMP, QMS standards
  • Good understanding of DFM and lean manufacturing
  • Excellent verbal, written, presentation and interpersonal skills
  • Strong analytical and problem-solving skills
  • Knowledge and/or hands-on experience with machine shop tools
  • Proficiency with SolidWorks required
  • Creative, self-motivated, flexible to work in a small company environment and assume a wide variety of tasks

Preferred Qualifications

  • Knowledge /experience with plastic injection molding
  • Masters’ degree or higher in Mechanical Engineering or Biomedical Engineering

 

Mechanical Testing & Fixture Design  Engineer – Milpitas, CA

 

There is an immediate opening for mechanical testing and fixture design engineer. Good understanding of how to design and set up tests is required. Responsibilities include designing unique tests, developing fixtures, and analyzing the data. Additional duties may include reporting failures, and assisting in improving manufacturing processes to prevent prototype failures, support R&D with component design work, test fixture design, support verification testing, and interface with manufacturing to implement new design updates into the pilot manufacturing line.

 

Responsibilities

  • Work with multi-disciplinary teams to define tests and perform verification testing
  • Design and build appropriate test fixtures for completing the tests
  • Assist engineering and bio team on evaluation of device failures and complete test reports to review improvements with the team
  • Collaborate with manufacturing to create product assembly tooling, fixtures and work instructions
  • Assist R&D and manufacturing in process development, including molding, bonding processes for parts, and component design
  • Comply with company’s policies and guidelines regarding quality and regulatory

Qualifications

  • BS in Mechanical Engineering
  • 3-5 years of industry experience
  • Must be hands on and adept at building and debugging fixtures
  • Fluent with SolidWorks
  • Excellent verbal, written, presentation and interpersonal skills
  • Strong analytical and problem-solving skills
  • Creative, self-motivated, flexible to work in a small company environment and assume a wide variety of tasks

Preferred Qualifications

  • Prior experience in a medical device company desired

 

Cell Biologist with Islet Cell Experience – San Jose, CA

This is an opportunity to participate at grounds level with possibility of high potential outcome. Technology focuses on cure for diabetes and requires islet cell or related experience.

 

C Level Opportunity – Milpitas, CA

 

There is a senior level leadership opportunity that requires prior experience with leading a neurological medical device company.

 

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Coronavirus: Treatments and Vaccines


Recently a science teacher said that treatment for covid with remdesivir or hydroxychloroquine is better than a vaccine. I said, treatment like that is good but a vaccine is better. She said, “no. since many people get adverse reactions from vaccines, a treatment is better”. So I decided to write this blog post. First, let us consider what are drug treatments and how they are different from vaccines.

Drug treatments: Currently over 70 companies are working on various drug treatments for novel coronavirus. Although this virus is novel, not all drugs being considered are entirely novel. For instance, like the previously considered malaria drug, hydroxychloroquine, Gilead’s drug, Remdesivir, that is in the news, is not a novel drug. Remdesivir is a broad spectrum antiviral drug that has been found to successfully prevent MERS coronavirus in rhesus monkeys. Besides antiviral drugs, there are other anti-inflammatory drugs. Scientists believe that in the end, what might work may be a sort of a cocktail or some combination of antiviral and anti-inflammatory drugs.

Drug treatments do not prevent Covid-19. These drugs are offered to patients who are already suffering from coronavirus. On the other hand, vaccines prevent people from contracting the disease in the first place.  

Drug treatments are not cures. 1) there isn’t a 100% response rate among people treated with remdesivir or any other treatment. So despite many drugs showing promise, there are a few people who will respond to a drug; many still die. 2) many who suffer from the disease but go on to recover, they still utilize huge amounts of hospital resources during their illness phase. 3) during the illness phase, these sick people also spread the virus with the possibility of making others (including healthcare professionals) sick. 4) even people who may recover with the help of these drugs from covid, may have suffered substantial damage to their lungs and that may reduce their lifespan or affect them in other ways.

Vaccines:  Vaccines prevent people from getting sick. So when people don’t get sick, they don’t spread the virus, don’t utilize healthcare resources, don’t infect healthcare professionals or others in the community, and don’t get any kind of long lasting damage to their lungs. Clearly, vaccine is a far superior way to deal with coronavirus.

Why are vaccines taking much longer than drugs for covid?

Virus, Pathogen, Infection, Biology

As I mentioned above, many of the drugs considered currently for treatment of covid are already in existence for some other illnesses or diseases. So there are existing drugs considered for either preventing covid deaths or preventing people from becoming sicker and helping them recover faster and ending hospital stays earlier.

Vaccines on the other hand, have to be developed. There are considerable challenges at each stage of vaccine research, development and manufacturing. First of all, pharmaceutical companies have decreased vaccine research and development in the last several years, because vaccine development and manufacturing is expensive, time consuming and offers smaller payback in terms of revenues. For each new virus and for all mutations, the vaccine has to be developed and then when the virus is not active then the vaccine is not useful. Clinical studies take place during the research and development phase. Only if the studies show the vaccine to be safe and effective then the vaccine proceeds to the next phase where it has to be manufactured in large quantities required.

During a pandemic like this one, not only do we need a vaccine quickly but the world will also need  hundreds of millions of doses for the entire world population.  Fortunately, pharma companies, scientists from all over the world, billionaires like Bill Gates and Governments and countries have stepped up to tackle this challenge, with an unprecedented spirit of collaboration.  There are measured expectations for an effective vaccine to be available within 12 to 18 months. That is an unprecedented and highly aggressive timeline. Bill Gates has offered to support manufacturing of top 7 candidates during the research and development phase. That means, even without the proof of effectiveness of any of them, he will foot the bill for manufacturing all of them, in the hope that at least a couple of them will prove to be safe and effective and the world will get required doses speedily. Meanwhile, countries like India are getting ready for manufacturing of vaccines. India has proven capability and expertise to ramp up production of vaccines, while keeping costs down. Regulatory hurdles are likely to be less severe as US FDA and other regulatory bodies have promised EUA (emergency use authorization) for drugs and vaccines that may help contain covid.

If drugs like Remdesivir work then that will help some people recover and recover faster; so let us hope that any one of these drugs alone or in combination with other drugs will reduce mortality, shorten hospital stays, and help reduce spread of covid. But ultimately we need a vaccine for covid-19 and the way in which entire world is coming together, gives much hope for availability of a speedy vaccine.

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Herd Immunity for Covid-19?


Have you noticed only politicians and some lay people talk about #HerdImmunity? Scientists and business people seem to be talking about #testing, cure and vaccines. Amazon is planning its own tests just for their own workforce. Some of my clients are doing the same. Chemicals for covid-19 diagnostic tests are hard to find but businesses may tap into their global connections to acquire them.

So what is herd immunity?

A person is answering question relating to herd immunity.

Herd immunity is an epidemiological concept coming from an idea that ultimately if enough people in a population are immune to a disease then it stops spreading. For instance, if 80 people out of 100 can’t get the disease than the 20 people who can get it remain protected because they may be unlikely to actually get exposed.   

Herd immunity can be achieved in a community in one of the two primary ways.

1) Vaccine access and acceptance:

If a significant number of people get access to the vaccine, they accept it and avail of the opportunity and become non carriers of the virus then even if 5% may not have gotten the vaccine, they may not get the disease because there may not be enough people to get it from. But we don’t yet have a vaccine for coronavirus.

2) Virus has a free rein: 

This is how the politicians have been speaking of herd immunity. Herd immunity is also connected to the argument that the best way to end the social distancing is to allow the virus to run free or at least almost free and in the end the population will achieve herd immunity. This sounds like a creative new idea rather than something horrifying that we should try to avoid at all costs. But let us remember that this only happens after VAST numbers in a population, get infected. So that requires us to “sacrifice the vulnerable on the altar of the economy in vast numbers.”

What kind of vast numbers of fatality might we be speaking of? As per some estimates, herd immunity for Covid-19 can occur after at least 60 to 70 percent of the population develops immunity.  That means at least 60 to 70 percent of the people have to first get infected. Moreover, these have to be random infections. That means, several people would die with a highly contagious virus running free in a society, before herd immunity is achieved.  This would overwhelm our healthcare system and several healthcare professionals would die while working in a high virus load environment.

Even with all our social distancing measures in place, we have a high death count that has brought healthcare system on the brink of overwhelm, in many places. In New York, a dense state with high international travel, there was a death count of almost 15,000 in a population of less than 10M. Healthcare professionals from several other geographical regions traveled to New York to lend help. Can you imagine every state taxed that way beyond their maximum capacity to care for the patients? And that is the reason that scientists and business leaders are not advocating herd immunity as an ultimate preventive measure. We can be lay people and choose to remain ignorant and spread the forwards and myths about herd immunity OR we can listen to what science has to say over what the politicians may be advocating.

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દ્રષ્ટિકોણ 107: વાંચન એટલે (on reading)


કસરત કરવાથી શરીર તંદુરસ્ત રહે છે તે પ્રમાણે વાંચન થી મન તંદુરસ્ત રહે છે.  વાંચન પ્રાર્થના નો પણ એક પ્રકાર છે. જે રીતે ખરા મન થી પ્રભુ ભજન માં વ્યસ્ત વ્યક્તિ ને આસ પાસ નું ધ્યાન રહેતું નથી તે રીતે વાંચન માં ધ્યાનગ્રસ્ત હોઈએ ત્યારે આપણે તેમાં એવા ડૂબી જઈએ છીએ કે આજુબાજુ ના વાતાવરણ ને ભૂલી જઈએ છીએ. વાંચન થી સહાનુભૂતિની કેળવાય છે. થોડીવાર માટે જયારે આપણે બીજાના જૂતામાં ચાલીએ છીએ, બીજાની નજરે દુનિયાને નિહાળીએ છીએ ત્યારે સ્વાભાવિક રીતેજ બીજા લોકો પ્રત્યે સહાનુભૂતિ અને મમતા જાગે છે.

માર્ક ટ્વેઇન જે અમેરિકન લેખન સાહિત્યના પિતા સમાન ગણાય છે. તેમણે – http://bit.ly/2QIVNlM 

મિસિસિપી નદી ઉપર કામ કરતા નદીના કિનારે રહેતા ખેડૂતો, તેમની પત્નીઓ, જુગારીઓ, નેટિવ અમેરિકનો, બ્લેક અમેરિકનો, મોટા ઝાડ કાપનાર લમ્બરજેક્સ વગેરે  લોકો નું અને તેમની રહેણીકહેણી નું બારીકાઈથી નિરીક્ષણ કરીને સુંદર વર્ણન કર્યું છે. તેમના લેખન દ્વારા વાચકોને અમેરિકાની સાંસ્કૃતિક લેન્ડસ્કેપ વિષે સુંદર માહિતી જ નથી મળતી પરંતુ તેમના વાતાવરણ માં તે લોકો જોડે બેસીને મહેફિલ માણતા  હોઈએ અને તે બધા આપણા મિત્ર હોય તેવું લાગે છે. 

ખરું કહું તો વાંચન આપણને આમ તો ઘર થી દૂર દૂર લઇ જાય છે. પણ જ્યાં પહોંચીએ ત્યાં ઘર હોય તેવો માહોલ સર્જાવી આપે છે.  

Narrative, History, Dream, Tell, Fairy Tales, Book

 

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જગત કલ્યાણ માટે પ્રાર્થના 


Prayer, House, Corona, Coronavirus, Virus, Pray

અર્પણ કરું છું હું કેલીફોર્નીઆથી દર્શના
કરુણામય બ્રહ્માંડ પાસે મારી પ્રર્થના
કુદરત તારી વિસ્મયભરી સૃષ્ટિના માનમાં
સ્વિકારજે જગત કલ્યાણ માટે મારી ભાવના 

ભલે કરીએ મંત્ર જાપ સંતનામ ને પ્રાર્થના
અદભુત કુદરતને પહેલા પ્રણામ આપણા
માફ કરજે તારી બલિહારી અમે ન સમજ્યા
તારી સૃષ્ટિના દરેક કણ સુધી પહોંચે આ ભાવના
વૈજ્ઞાનિકોને અર્પણ બીજી અભ્યર્થના
ડોક્ટર નર્સ ને કાળજીકારોને ત્રીજી અર્ચના
આરોગ્ય વ્યાવસાયિકો (હેલ્થ પ્રોફેશનલ્સ) ને નમ્ર યાચના
અમ સંગ સાંભળજો તમારી આરોગ્યતા
લોકકલ્યાણકર્તાઓ માટે ચોથી પ્રાર્થના
બીજા નું ભાડું ભરવાનું, માસ્ક બનાવવાના
ગ્રોસરી લાવવાની, ગાઉન સીવવાના
તેમને વંદન, તેમના સ્થાસ્થ્યની પ્રાર્થના
પાંચમે કલ્યાણ થાય અબોલ પશુ પક્ષીઓના
સર્વ જગત કલ્યાણ માટે અર્પણ આ પ્રાર્થના 

 

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Lessons from Shanghai, China: Strategy for containment & care during Covid-19 


Recently, CABS, the Chinese American Biopharmaceutical Society hosted a webinar on the topic,  “COVID-19 Clinical Treatment and Research Experiences from China”, with Dr. Wenhong Zhang. Dr. Zhang is Director of the Department of Infectious Diseases in Shanghai and leader of Anti-Covid-19 team. He is also on Chinese Society of Infectious Disease and with Chinese Association of Internal Medicine. During the fight against Covid-19, Dr. Zhang led the Shanghai team to formulate a clinical treatment and containment plan.

 

Night, City, Shanghai, Asia, East, Architecture, Urban

An article in scientific publication Lancet predicted in late January that after Wuhan, Shanghai can be the epicenter of the virus with as many as 800,000 cases. However, with very early focus on containment and reasonable social distancing (even without complete lockdown measures), Shanghai managed to restrict the spread to about 4,000 cases. The key was that the healthcare system went on full alert when they had their very first case of a person traveling from Wuhan.

 

Dr. Zhang shared many details of their process for containing the spread and answered questions sent by the audience members. I have captured a few of the nuggets from his talk and I am sharing them below.


Diagnosis: Immediately they optimized diagnostics and did all needed tests for suspected patients. Shanghai made separate fever clinics and all patients who met 1 epidemiology criteria plus one clinical criteria were encouraged to go to these clinics. Suspected Covid-19 patients were sent to separate quarantine wards for full testing, and while they awaited results.  If the results came back positive, they were sent to separate hospitals for quarantine stay and were tested again, before release.

 

Further, while in the US some hospitals first tested for flu and other viruses and if the patient tested positive for any of them then they were not tested for coronavirus, Shanghai tested all suspect cases for coronavirus. Dr. Zhang said that they have found that there are a lot of co-infections so a person can have regular flu virus plus coronavirus. Additionally, they found a high negative rate in PCR testing, while a positive rate was around 70%. Therefore, despite negative test results, if the patient was highly suspect than they did more testing. They did not rely on CT scans because they found that a chest CT cannot precisely confirm Covid and all cases needed molecular diagnosis.

 

Detailed process in place: Shanghai had a very detailed process in place for the steps to be taken for patients in the first screen, then first test, then when tested positive, if tested negative, and for followup.  Timely diagnosis and timely distancing and quarantine is very important, said Dr. Zhang. Immediate separation and early control of local transmission is the key to stop the Covid-19 disease spread, said Dr. Zhang.  This is something that did not happen in Italy. Almost all of their early cases were of foreigners. Eventually all of their cases and high death toll has been among the local population.

 

Treatment Options: Dr. Zhang shared that over 95% of the patients recovered and eventually were released. One patient died. There has been debate around anti-viral treatments. Dr. Zhang said, these treatments don’t seem to be effective. China also used hydroxychloroquine (widely touted malaria drug) to treat Covid patients and did not find it to be effective. However, it can have compassionate use since it shows little lasting side effects, said Dr. Zhang. Although he did not observe clinical evidence of anticoagulants, he said, it is possible that early anticoagulation may block clotting and eventually reduce the risk of major organ damage.

 

Respiratory Treatment: Dr. Zhang shared that the most fundamental treatment in keeping patients alive is respiratory treatment. We have a narrow window to stop progression from mild symptoms to severe symptoms, said Dr. Zhang. Low and short duration corticosteroids may stop progression and we need more studies to find that out. Life support for critically ill patients is crucial. Timely intervention with mask oxygen inhalation, nasal cannula oxygen therapy, mechanical ventilation etc. can prolong life until the body’s immune system gets critical time to fight off the virus.

 

Medical Personnel: In Shanghai, strict following of protocol, translated into not a single infection spreading into the healthcare professionals. Highly qualified and standardized process included appropriate PPE (personal protective equipment) with gowns, goggles, masks, double layer gloves and shoe covers. Healthcare professionals were asked to never share a meal with others at home, during the time this contagion was active. As far as possible, the patients were kept in negative pressure wards and surfaces were cleaned with disinfectants every 4 hours.

My Comments
Stay tuned for my next article on how China effectively used high tech, specifically big data and coupled it with public awareness and public participation to contain the virus. Please note: I am not a fan of, or in any way endorsing communism or authoritarianism. And yet, perhaps there are lessons even for Western democracies, to pay heed to early signs and implement containment strategies. And that is exactly what Bill Gates was referring in 2015, when he spoke at TedTalks and warned us about a virus pandemic that can possibly kill millions. That is what various scientists have been warning of, for years.

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દ્રષ્ટિકોણ 107: અનામી એટલે (on nameless)


અનામી એટલે………

અનામી એટલે… વિષય ઉપર…. માત્ર વ્યક્તિઓને જ નહિ, પરંતુ લાગણીઓને પણ આપણે નામ આપીએ છીએ અને ક્યારેક તે નામ પ્રબળ લાગણીઓને દર્શાવવા માટે પૂરક નથી. 

Head, Face, Isolation, Loneliness, Externally, Foreign

અત્યારે કોરોનવાઈરસ ને લીધે આપણે મળવાનું નથી અને અંતર રાખવાનું છે. ઘરમાં સાથે રહેતા પણ એકબીજાને મોકળાશ આપવી પડે છે. મારી દીકરી કોરોનવાઈરસ દર્દીઓ જોડે કામ કરે છે તેને હું મળી સકતી નથી  પણ તેને યાદ રાખીને બે વાત કરું છું. 

ખલિલ જિબ્રાને કહ્યું છે ।…

“તમારી એકતામાં અંતર રહેવા દ્યો. વચ્ચે થોડી જગા રાખો, એકમેકને મોકળાશ આપો અને આકાશના પવનને વચ્ચે નૃત્ય કરવા દો. પ્રેમ કરો પણ પ્રેમ ને બંધન ન બનાવો।  સાથે ગાઓ, આનંદ કરો, પરંતુ દરેકને એકલા રહેવા દો, જેમ વીણા ના તાર અલગ હોય છે, છતાં સાથે મળીને સંગીત ના સુર કાઢે છે. એકમેક જોડે ઉભા રહો પણ એકદમ નજીક નહિ; એ રીતે જેમ મંદિર ના થાંભલા સાથે ઉભા રહીને આખું મંદિર ઊંચકી રાખી શકે છે તેમ”.

બીજું, જીવન ના સાચા બંધનોને અકબંધ રાખનાર એક અનામી લાગણી, અનામી તાકાત છે, જે તેમને તૂટવા નહિ દ્યે. તેવા ઊંડા બંધન ને કદાચ શબ્દોમાં વર્ણવી ન શકું તો પણ આપણે જાણીએ છીએ તેવી અનામી તાકાત પ્રેમ વચ્ચે અંતર હોય ત્યારે પણ પ્રેમ ના તાંતણાને ટકાવી રાખે છે.  

 

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Summit, IBM supercomputer is our recent hero in the fight against Covid-19


The looming threat of Covid-19 and the grim reality of the toll that novel coronavirus takes on humankind, makes it imperative that we find a way to prevent the spread faster and with less cost. Currently nine out of ten drug therapies fail mostly between phase 1 trials and regulatory approval. The estimated cost of developing a new treatment is around staggering US $2.6 billion.  While this article won’t address it, I want to mention that many bio/pharma companies are working with repurposed drugs to find a cure and at least 69 drugs have been identified as treatment possibilities. Drugs also have side effects and need to be tested for safety. Let us focus for a while on search for the vaccine.

Artificial intelligence icon AI, isometric cloud computing concept, data mining, isometric, neural network, machine programming, vector

Many companies including Moderna, CureVac and BioNTech are working on vaccines. With the help of  Machine Learning, Artificial Intelligence and other technologies the hunt for new pharmaceuticals and appropriate chemicals is expected to be quicker, cheaper and more effective. Novel coronavirus presents the most unprecedented challenge to date because of the speed with which it spreads. 

Who better than a supercomputer made by a company that has been on the cutting edge of innovation for over a century, to take on this speed challenge? IBM scientists instructed the world’s fastest computer to tackle this challenge at its Oak Ridge National Laboratory in Tennessee. Summit can run 200 quadrillion computations per second. The scientists ran thousands of simulations to analyse which drug compounds could stop the coronavirus from infecting the host cells. 

Summit, an IBM supercomputer equipped with the “brain of AI” identified 77 compounds (from over 8000 compounds) that could be efficacious in preventing coronavirus from spreading in the host.  This is promising news in humanity’s quest for an effective vaccine against the virus. These findings are published in the journal ChemRxiv and give us hope although road is still long to get there.

With increasing computer processing power and advanced algorithms, AI has been employed to analyze large data sets with greater efficiency and will likely lead to many exciting innovations.  While AI and ML show promise to change every industry sector for the better, artificial intelligence, machine learning and deep learning have become the most widely discussed topics in the healthcare sector and the excitement keeps growing.  

I will be looking forward to hearing about new innovations AI/ML at #TiEcon2020. Stay tuned for new dates for the conference at http://www.tiecon.org and on this blog.

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દ્રષ્ટિકોણ 106: જીવન એટલે (on life)


Flower, Life, Crack, Desert, Drought, Survival

ઓસ્ટ્રિયામાં વિક્ટર ફ્રેન્કલ નામના એક ન્યુરોલોજિસ્ટ વસતા હતા. તેમને નાઝી કોન્સેન્ટ્રેશન કેમ્પ માં કેદ કરવામાં આવેલ અને ત્યાં અસહ્ય હાલતમાં રહેતા રહેતા તેમણે એક ચોપડી લખવાનું વિચાર્યું અને કેદ માંથી બહાર આવ્યા બાદ તે પ્રકાશિત થઇ તે ચોપડી નું નામ છે – “અર્થ ની શોધ” સર્ચ ફોર મીનિંગ. જીવન માં આપણે કૈક મીનિંગ કૈક અર્થ શોધતા હોઈએ છીએ. અર્થ વગરનું જીવન ડેડ જીવન છે. 

 

ફ્રેન્કલ ના કહેવા પ્રમાણે જીવન ત્રણ રીતે અર્થસભર બને છે. 1) હેતુપૂર્ણ કાર્ય। રિટાયર્ડ માણસ અથવા ઘરકામ કરતી સ્ત્રી પણ હેતુપૂર્ણ કાર્ય કરતા હોય છે જેમાં તેમને સંતોષ પ્રાપ્ત થાય છે ને જીવન ની આશા બનેલી રહે છે.  2) પ્રેમ। તેમની અનુભૂતિ નું વર્ણન કરતા ફ્રેન્કલ કહે છે કે ગાર્ડ તેમને મારી મારીને કામ કઢાવે ત્યારે પણ તેઓ તેમના મનમાં તેમની પત્ની જોડે વાત કરી લેતા. અવારનવાર તેમને તેમની પત્ની નો અવાજ સંભળાતો અને તેઓ માનતા હતા કે અને તેમના કુટુંબ તરફ ના પ્રેમ ને લીધે અને ફરી મળવાની આશાએ જ તેમને જીવાડી રાખ્યા. અને 3) પડકારનો સામનો કરવાની હિમ્મત. સુખ અને દુઃખ જીવનનાજ બે પાસા છે. સુખ ઘણીવાર ઢોલ વગાડતું આવે છે જયારે દુઃખ અવાજ વગર આવીને ઉભું રહે છે. પણ જો મુસીબત અને દુઃખ નો પડકાર જીલવાની હિમ્મત વ્યક્તિ હારી જાય ત્યારે જીવન ધીમે ધીમે બુજાય જાય છે. ફ્રાંકેલે કહ્યું કે વ્યક્તિ પાસેથી તેની દરેક સ્વતંત્રતા બીજા છીનવી શકે છે, સિવાય એક. ગમે તે પરિસ્થિતિ માં કેવું વલણ ધારણ કરવું તે આપણા હાથ માં છે. અને તે સ્વતંત્રતા માં જે વ્યક્તિ હકારાત્મક અભિગમ ધારણ કરી ને મુસીબત નો સામનો કરે છે તે વલણ તેને જીવન અને અર્થ બક્ષે છે. 

 

અને હેતુ, અર્થ, પ્રેમ, અને હકારાત્મક વલણ સાથેની જિંદગી એટલે જીવન.

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Impact of Edge Computing on Changing Work Landscape in Post Covid-19 World 


With the coronavirus travel restrictions and stay in place edicts, there are concerns regarding the future of work. Coronavirus has impacted and disrupted supply chains, has led to canceled conferences and trainings, including postponement of TiEcon 2020, and employees are asked to work from home.

 

However, it is not just a matter of asking people to work remotely, with a laptop. People will need the right tools, secure access to the company network through VPN and other collaboration tools. Additionally, people will need devices that are more powerful and in some cases are smart enough to overtake cloud capabilities to drive new and exciting IOT applications. Increasingly, powerful and smart devices are already helping reduce data center loads.  This ability to do on-device processing and refined analytics remotely, is what is called “edge computing”.  

 

In remote locations where connectivity to centralized locations is limited, edge computing enables speed and efficiency by bringing computation power closer to IOT sensors, and smart phones and closer to end users. As everyday devices continue to become more smart and powerful, employees will be doing more with them and there will be more opportunities to create value for external and internal customers in our changing employment landscape.

 

TiEcon2020 has an excellent lineup of speakers on edge computing, during its upcoming conference before the end of this year. Stay tuned. For tracks and continuous updates, go to www.tiecon.org .

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